Bio-neural circuitry represents the next evolution of computing in the 24th century. These "gel-packs" are composed of synthetic cerebral neurons suspended in a gel matrix. These enable the gel-packs to mimic brain functions. They are designed to mimic brain functions and thus decrease reaction times. Gel-packs are banded together with old-style isolinear chips to form a top of the notch computer system. Gel-packs were introduced on Starfleet vessels beginning with the Intrepid class.

The bio-neural systems consist of a series of gel packs that contain synthetic neural fibers suspended in biomimetic gel, a gelatinous organic medium. Each pack consists of a transparent, flexible casing that contains the fluid, and a metallic interface bar at the top that can be plugged into the ship's systems, meaning that it can be swapped as easily as an isolinear chip. The neural fibers in the gel pack are created artificially and resemble humanoid neurons, while the bioneural systems mimic the working of the human-oid brain and are significantly taster and more efficient than optical circuitry. The fibers in an individual gel pack are capable of making billions of connections, thus generating an incredibly sophisticated and responsive computing architecture. This kind of organic circuitry allows computers to 'think' in very similar ways to living organisms; by using 'fuzzy logic, they can effectively guess the answer to complex questions. The gel packs can operate independently of other systems or, if necessary, they can use the isolinear cores to perform number-crunching operations and for data reference. The gel packs are used in systems throughout the U.S.S. Voyager, but their principal function is to make instantaneous navigational computations. For example, they can calculate course corrections in real time for optimal fuel consumption.

However, gel-packs suffer from one main problem not inherent in isolinear chips. It is possible for the gel-packs to become infected with various virii, making the packs non-functional. Once these packs "catch cold," they must be replaced.